Abstract Bench Background While the composition of the gut microbiome has now been well described by several large-scale studies, models that can account for the range of microbiome compositions that have been observed are still lacking.One model that has been well studied in macro communities and that could be useful for understanding microbiome a
Abstract Hypoxia promotes aggressive tumor phenotypes and mediates the recruitment of suppressive T cells in invasive breast carcinomas.We investigated the role of hypoxia in relation to T-cell regulation in ductal carcinoma in situ (DCIS).We designed a deep learning system tailored for the tissue architecture complexity of DCIS, and compared pure
Background: Multiple sclerosis (MS) is a chronic autoimmune and neuroinflammatory disease of the central nervous system characterized by peripheral activation of immune-inflammatory pathways which culminate in neurotoxicity causing demyelination of central neurons.Nonetheless, the pathophysiology of relapsing-remitting MS (RRMS)-related chronic fat